Antimicrobial Sub-MIC induces Staphylococcus aureus biofilm formation without affecting the bacterial count.

ABSTRACT:

Background

Biofilm formation is an essential virulence factor that creates a highly protected growth mode for Staphylococcus aureus (S. aureus) to survive in any hostile environment. Antibiotic sub-minimal inhibitory concentration (sub-MIC) may modulate the biofilm formation ability of bacterial pathogens, thereby affecting bacterial pathogenesis and infection outcomes. Intense antimicrobial therapy to treat biofilm-associated infections can control the pathogenic infection aggravation but cannot guarantee its complete eradication.

Objective

This study aimed to assess the sub-MICs effect of 5 different antimicrobial classes on biofilm-forming capacity among Staphylococcus aureus clinical isolates using three different biofilm quantitation techniques.

Methods

In this s

SUBMITTER: Elawady R 

PROVIDER: S-EPMC11438285 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature