Immunomodulatory effects of Huaier granule in cancer therapy: a meta-analysis of randomized controlled trials.

ABSTRACT:

Background

This meta-analysis aimed to summarize the immunomodulatory effect of Huaier (Trametes robiniophila Murr) granule as adjuvant therapy in patients with cancer. MATERIALS AND METHODS: Two authors conducted a search for literature indexed on various databases including PubMed, Embase, Cochrane Library, CNKI, Sinomed, VIP, and WanFang. Randomized controlled trials (RCTs) that investigated the immunomodulatory effect of Huaier granule as adjuvant therapy in cancer patients were included. The outcome of interest included T-lymphocyte subsets (CD3⁺, CD4⁺, CD8⁺ and CD4⁺/CD8⁺), immunoglobulin (IgA, IgG, IgM), and natural killer (NK) cells.

Results

We identified 29 RCTs involving a total of 2206 cancer (including hepatoc

SUBMITTER: Zang Y 

PROVIDER: S-EPMC11438288 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature