Causal effects of cardiovascular health on five epigenetic clocks.

ABSTRACT:

Background

This work delves into the relationship between cardiovascular health (CVH) and aging. Previous studies have shown an association of ideal CVH with a slower aging rate, measured by epigenetic age acceleration (EAA). However, the causal relationship between CVH and EAA has remained unexplored.

Methods and results

We performed genome-wide association studies (GWAS) on the (12-point) CVH score and its components using the Taiwan Biobank data, in which weighted genetic risk scores were treated as instrumental variables. Subsequently, we conducted a one-sample Mendelian Randomization (MR) analysis with the two-stage least-squares method on 2383 participants to examine the causal relationship between the (12-point) CVH score and EAA. As a result, we observed a significan

SUBMITTER: Sung HL 

PROVIDER: S-EPMC11438310 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature