MiR-NPs-RVG promote spinal cord injury repair: implications from spinal cord-derived microvascular endothelial cells.

ABSTRACT:

Background

Spinal cord injury (SCI) often leads to a loss of motor and sensory function. Axon regeneration and outgrowth are key events for functional recovery after spinal cord injury. Endogenous growth of axons is associated with a variety of factors. Inspired by the relationship between developing nerves and blood vessels, we believe spinal cord-derived microvascular endothelial cells (SCMECs) play an important role in axon growth.

Results

We found SCMECs could promote axon growth when co-cultured with neurons in direct and indirect co-culture systems via downregulating the miR-323-5p expression of neurons. In rats with spinal cord injury, neuron-targeting nanoparticles were employed to regulate miR-323-5p expression in residual neurons and promote function recovery.

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SUBMITTER: Li C 

PROVIDER: S-EPMC11438374 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature