Ferroptosis - a potential feature underlying neratinib-induced colonic epithelial injury.

ABSTRACT:

Purpose

Neratinib, a small-molecule tyrosine kinase inhibitor (TKI) that irreversibly binds to human epidermal growth factor receptors 1, 2 and 4 (HER1/2/4), is an approved extended adjuvant therapy for patients with HER2-amplified or -overexpressed (HER2-positive) breast cancers. Patients receiving neratinib may experience mild-to-severe symptoms of gut toxicity including abdominal pain and diarrhoea. Despite being a highly prevalent complication in gut health, the biological processes underlying neratinib-induced gut injury, especially in the colon, remains unclear.

Methods

Real-time quantitative polymerase chain reaction (RT-qPCR) and histology were integrated to study the effect of, and type of cell death induced by neratinib on colonic tissues collected from female Albi

SUBMITTER: Nguyen TPM 

PROVIDER: S-EPMC11438713 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature