Gene Regulatory Network Analysis of Decidual Stromal Cells and Natural Killer Cells.

ABSTRACT: Human reproductive success relies on the proper differentiation of the uterine endometrium to facilitate implantation, formation of the placenta, and pregnancy. This process involves two critical types of decidual uterine cells: endometrial/decidual stromal cells (dS) and uterine/decidual natural killer (dNK) cells. To better understand the transcription factors governing the in vivo functions of these cells, we analyzed single-cell transcriptomics data from first-trimester terminations of pregnancy, and for the first time conducted gene regulatory network analysis of dS and dNK cell subpopulations. Our analysis revealed stromal cell populations that corresponded to previously described in vitro decidualized cells and senescent decidual cells. We discovered new decidualization driving tran

SUBMITTER: Rytkonen KT 

PROVIDER: S-EPMC11438719 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature