Integrative cartilage repair using acellular allografts for engineered structure and surface lubrication in vivo.

ABSTRACT: The repair of articular cartilage after damage is challenging, and decellularized tissue offers a possible treatment option to promote regeneration. Here, we show that acellular osteochondral allografts improve integrative cartilage repair compared to untreated defects after 6 months in an ovine model. Functional measures of intratissue strain/structure assessed by MRI demonstrate similar biomechanics of implants and native cartilage. Compared to native tissue and defects, the structure, composition, and tribology of acellular allografts preserve surface roughness and lubrication, material properties under compression and relaxation, compositional ratios of collagen:glycosaminoglycan and collagen:phosphate, and relative composition of types I/II collagen. While high cellularity was observe

SUBMITTER: Barthold JE 

PROVIDER: S-EPMC11438864 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature