Experience of Euclidean geometry sculpts the development and dynamics of rodent hippocampal sequential cell assemblies.

ABSTRACT: Euclidean space is the fabric of the world we live in. Whether and how geometric experience shapes our spatial-temporal representations of the world remained unknown. We deprived male rats of experience with crucial features of Euclidean geometry by rearing them inside spheres, and compared activity of large hippocampal neuronal ensembles during navigation and sleep with that of cuboid cage-reared controls. Sphere-rearing from birth permitted emergence of accurate neuronal ensemble spatial codes and preconfigured and plastic time-compressed neuronal sequences. However, sphere-rearing led to diminished individual place cell tuning, more similar neuronal mapping of different track ends/corners, and impaired pattern separation and plasticity of multiple linear tracks, coupled with reduced pre

SUBMITTER: Farooq U 

PROVIDER: S-EPMC11438871 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature