Imaging genetics of language network functional connectivity reveals links with language-related abilities, dyslexia and handedness.

ABSTRACT: Language is supported by a distributed network of brain regions with a particular contribution from the left hemisphere. A multi-level understanding of this network requires studying its genetic architecture. We used resting-state imaging data from 29,681 participants (UK Biobank) to measure connectivity between 18 left-hemisphere regions involved in multimodal sentence-level processing, as well as their right-hemisphere homotopes, and interhemispheric connections. Multivariate genome-wide association analysis of this total network, based on genetic variants with population frequencies  >1%, identified 14 genomic loci, of which three were also associated with asymmetry of intrahemispheric connectivity. Polygenic dispositions to lower language-related abilities, dyslexia and left-handedness

SUBMITTER: Amelink JS 

PROVIDER: S-EPMC11438961 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature