Determination of key hub genes in Leishmaniasis as potential factors in diagnosis and treatment based on a bioinformatics study.

ABSTRACT: Leishmaniasis is an infectious disease caused by protozoan parasites from different species of leishmania. The disease is transmitted by female sandflies that carry these parasites. In this study, datasets on leishmaniasis published in the GEO database were analyzed and summarized. The analysis in all three datasets (GSE43880, GSE55664, and GSE63931) used in this study has been performed on the skin wounds of patients infected with a clinical form of leishmania (Leishmania braziliensis), and biopsies have been taken from them. To identify differentially expressed genes (DEGs) between leishmaniasis patients and controls, the robust rank aggregation (RRA) procedure was applied. We performed gene functional annotation and protein-protein interaction (PPI) network analysis to demonstrate the p

SUBMITTER: Safaei M 

PROVIDER: S-EPMC11438978 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature