Atherosclerosis quantification and cardiovascular risk: the ISCHEMIA trial.

ABSTRACT:

Background and aims

The aim of this study was to determine the prognostic value of coronary computed tomography angiography (CCTA)-derived atherosclerotic plaque analysis in ISCHEMIA.

Methods

Atherosclerosis imaging quantitative computed tomography (AI-QCT) was performed on all available baseline CCTAs to quantify plaque volume, composition, and distribution. Multivariable Cox regression was used to examine the association between baseline risk factors (age, sex, smoking, diabetes, hypertension, ejection fraction, prior coronary disease, estimated glomerular filtration rate, and statin use), number of diseased vessels, atherosclerotic plaque characteristics determined by AI-QCT, and a composite primary outcome of cardiovascular death or myocardial infarction over a median fo

SUBMITTER: Nurmohamed NS 

PROVIDER: S-EPMC11439108 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature