Predictors of cardiac disease in duchenne muscular dystrophy: a systematic review and evidence grading.

ABSTRACT:

Background

Duchenne muscular dystrophy (DMD) is a rare disease that causes progressive muscle degeneration resulting in life-threatening cardiac complications. The objective of this systematic literature review was to describe and grade the published evidence of predictors of cardiac disease in DMD.

Methods

The review encompassed searches of Embase, MEDLINE ALL, and the Cochrane Database of Systematic Reviews from January 1, 2000, to December 31, 2022, for predictors of cardiac disease in DMD. The certainty of evidence (i.e., very low to high) was assessed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) framework.

Results

We included 33 publications encompassing 9,232 patients with DMD. We found moderate- to high-quality evidence

SUBMITTER: Landfeldt E 

PROVIDER: S-EPMC11439250 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature