Paternal preconception donepezil exposure enhances learning in offspring.

ABSTRACT:

Background

Recent research has indicated that parental use of central nervous system-targeting medications during periconceptional periods may affect offspring across various developmental and behavioral domains. The present study sought to investigate the potential influence of paternal use of donepezil, a specific reversible central acetylcholinesterase inhibitor that activates the cholinergic system to promote cognition, on offspring.

Results

In this study, male rats were bred after 21 days of oral donepezil administration at a dose of 4 mg/kg to generate F1 offspring. Both male and female F₁ offspring displayed enhanced performance in learning and short-term memory tests, including novel object recognition, Y maze, and operant learning. Transcriptomic analysis revealed n

SUBMITTER: Fan G 

PROVIDER: S-EPMC11439325 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature