Maternal HIV infection and the milk microbiome.

ABSTRACT:

Background

Children born to women with HIV but who do not become HIV infected experience increased morbidity and mortality compared with children born to women without HIV. The basis of this increased vulnerability is unknown. The microbiome, specifically the infant gut microbiome, likely plays an important role in infant immune development. The human milk microbiome is thought to have an important role in the development of the infant gut and therefore, if perturbed, may contribute to this increased vulnerability. We investigated the effects of HIV and its therapies on the milk microbiome and possible changes in the milk microbiome before or after infant HIV infection.

Results

Seven-hundred fifty-six human milk samples were selected from three separate studies conducted ove

SUBMITTER: Tobin NH 

PROVIDER: S-EPMC11439335 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature