Clinical characteristics and a diagnostic model for high-altitude pulmonary edema in habitual low altitude dwellers.

ABSTRACT:

Background

The fatal risk of high-altitude pulmonary edema (HAPE) is attributed to the inaccurate diagnosis and delayed treatment. This study aimed to identify the clinical characteristics and to establish an effective diagnostic nomogram for HAPE in habitual low altitude dwellers.

Methods

A total of 1,255 individuals of Han Chinese were included in the study on the Qinghai-Tibet Plateau at altitudes exceeding 3,000 m. LASSO algorithms were utilized to identify significant predictors based on Akaike's information criterion (AIC), and a diagnostic nomogram was developed through multivariable logistic regression analysis. Internal validation was conducted through bootstrap resampling. Model performance was evaluated using ROC curves and the Hosmer-Lemeshow test.

Results

SUBMITTER: Li Q 

PROVIDER: S-EPMC11439376 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature