Deciphering regulatory patterns in a mouse model of hyperoxia-induced acute lung injury.

ABSTRACT:

Background

Oxygen therapy plays a pivotal role in treating critically ill patients in the intensive care unit (ICU). However, excessive oxygen concentrations can precipitate hyperoxia, leading to damage in multiple organs, with a notable effect on the lungs. Hyperoxia condition may lead to hyperoxia-induced acute lung injury (HALI), deemed as a milder form of acute respiratory distress syndrome (ARDS). Given its clinical importance and practical implications, there is a compelling need to investigate the underlying pathogenesis and comprehensively understand the regulatory mechanisms implicated in the development of HALI.

Results

In this study, we conducted a mouse model with HALI and performed regulatory mechanism analysis using RNA-seq on both HALI and control group. Compr

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11439394 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature