Effects of tobacco nitrate content on free radical levels in mainstream smoke.

ABSTRACT: Tobacco smoke free radicals play an important role in the development of smoking related adverse health effects. We previously reported that gas phase (GP) radicals vary greatly by cigarette brand and tobacco variety and are highly correlated with levels of NNK in smoke. Since NNK production in tobacco is dependent on nitrate, we proposed that GP radical production may also be associated with tobacco nitrate content. To test this, we examined the relationship between intrinsic nitrate levels in 15 individual tobacco types and the levels of free radicals delivered in mainstream smoke from cigarettes produced from these tobaccos. Intrinsic nitrate levels varied >250-fold among the tobacco types, ranging from <0.1 mg/g tobacco in the Bright Leaf types to 24.1 ± 0.4 mg/g in Light Fire Cured Vi

SUBMITTER: Mocniak LE 

PROVIDER: S-EPMC11439502 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature