Bornite (Cu₅FeS₄) nanocrystals as an ultrasmall biocompatible NIR-II contrast agent for photoacoustic imaging.

ABSTRACT: In this study, we demonstrate the potential of the bornite crystal structure (Cu₅FeS₄) of copper iron sulfide as a second near infrared (NIR-II) photoacoustic (PA) contrast agent. Bornite exhibits comparable dose-dependent biocompatibility to copper sulfide nanoparticles in a cell viability study with HepG2 cells, while exhibiting a 10-fold increase in PA amplitude. In comparison to other benchmark contrast agents at similar mass concentrations, bornite demonstrated a 10× increase in PA amplitude compared to indocyanine green (ICG) and a 5× increase compared to gold nanorods (AuNRs). PA signal was detectable with a light pathlength greater than 5 cm in porcine tissue phantoms at bornite concentrations where in vitro cell viability was maintained. In vivo imaging of mi

SUBMITTER: Vincely VD 

PROVIDER: S-EPMC11439559 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature