Immunological correlates of suicidality among adolescents with internalizing symptoms.

ABSTRACT:

Background

Suicide is a leading cause of death in adolescents and young adults globally. Well-established risk factors for suicide are depression and past suicide attempts. People experiencing suicidality may represent a distinct neurobiological group of people with depression. Because converging evidence has implicated inflammation in depression, we sought to investigate relationships between suicidality and immune markers in youth experiencing diverse mood and anxiety symptoms. We hypothesized that adolescents with suicidality would exhibit a unique immune signature.

Methods

Adolescents underwent semi-structured interviews and completed self-reported measures to assess psychopathology, including suicidality (suicidal ideation, plans, or attempts). Fasting blood samples wer

SUBMITTER: Roske C 

PROVIDER: S-EPMC11439560 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature