Aconitate decarboxylase 1 mediates the acute airway inflammatory response to environmental exposures.

ABSTRACT:

Background

Environmental lipopolysaccharide (LPS) and microbial component-enriched organic dusts cause significant lung disease. These environmental exposures induce the recruitment and activation of distinct lung monocyte/macrophage subpopulations involved in disease pathogenesis. Aconitate decarboxylase 1 (Acod1) was one of the most upregulated genes following LPS (vs. saline) exposure of murine whole lungs with transcriptomic profiling of sorted lung monocyte/macrophage subpopulations also highlighting its significance. Given monocyte/macrophage activation can be tightly linked to metabolism, the objective of these studies was to determine the role of the immunometabolic regulator ACOD1 in environmental exposure-induced lung inflammation.

Methods

Wild-type (WT) mic

SUBMITTER: Schwab AD 

PROVIDER: S-EPMC11439662 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature