Relationship between type 1 diabetes and autoimmune diseases in european populations: A two-sample Mendelian randomization study.

ABSTRACT:

Background

Previous studies have suggested an association between Type 1 diabetes (T1D) and autoimmune diseases (AIDs), but the causal relationship remains unclear. Therefore, this study utilizes publicly available Genome-Wide Association Studies (GWAS) databases and employs a two-sample Mendelian Randomization (MR) approach to explore the causal relationships between T1D and systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and inflammatory bowel disease (IBD).

Methods

Summary GWAS data for T1D, SLE, RA, and IBD were downloaded from open GWAS databases and the International Inflammatory Bowel Disease Genetics Consortium (IIBDGC). We employed a series of methods to select instrumental variables closely related to T1D. To enhance the reliability of our conclusion

SUBMITTER: Xie W 

PROVIDER: S-EPMC11439667 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature