Association study reveals a susceptibility locus with male pattern baldness in the Han Chinese population.

ABSTRACT:

Introduction

Male pattern baldness (MPB), also known as androgenetic alopecia, represents the most prevalent form of progressive hair loss in humans. It is characterized by a distinctive pattern of hair loss progression from the scalp; however, its underlying mechanism remains elusive and is influenced by hereditary, immune, and environmental factors. Genome-wide association studies (GWASs) have uncovered numerous risk genes/loci among European individuals with MPB. However, the validation of these susceptibility genes/loci within Han Chinese men remains largely unexplored. The aim of this study was to investigate whether the 71 susceptibility loci identified in a recent GWAS among European men also confer risk for MPB in Chinese men.

Methods

Forty-seven single nucleotide po

SUBMITTER: Li Y 

PROVIDER: S-EPMC11439668 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature