Galectin-1 is associated with hematopoietic cell engraftment in murine MHC-mismatched allotransplantation.

ABSTRACT: Haploidentical hematopoietic cell transplantation (haplo-HCT) is associated with an increased risk of allograft rejection. Here, we employed a major histocompatibility complex (MHC)-mismatched allogeneic HCT (allo-HCT) murine model to better understand the role of Gal-1 in immune tolerance. Transplanted mice were classified into either rejected or engrafted based on donor chimerism levels. We noted significantly higher frequencies of CD4⁺ T cells, CD8⁺ T cells, natural killer cells, IFN-γ and TNF-α producing CD4⁺ T cells, and IFN-γ producing dendritic cells and macrophages in rejected mice. Conversely, we found significantly increased frequencies of regulatory T cells (Tregs), predominantly Helios⁺, IL-10-producing CD4⁺ T cells, type 1

SUBMITTER: Shaikh A 

PROVIDER: S-EPMC11439684 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature