Suppression of certain intestinal microbiota metabolites may lead to gestational diabetes in mice fed a high-fat diet.

ABSTRACT:

Background

We aim to establish a gestational diabetes mellitus (GDM) mouse model with mice fed with a high-fat diet (HFD) in comparison with pregnant mice with normal blood glucose levels to investigate the role of intestinal microbiota in the development of HFD-induced GDM.

Methods

We divided healthy 6-week-old female C57BL mice into an HFD-induced GDM group and a normal diet group. Their bacterial flora and metabolites in intestinal fecal exosomes were co-analyzed using 16 s multi-region sequencing and compared.

Findings

Alpha (α) diversity was lower within the model group compared to the control group. Beta (β) diversity was significantly different between the two groups. The relative abundances of Lactobacillus, Actinomyces, Rothia, and Bacter

SUBMITTER: Xie YP 

PROVIDER: S-EPMC11439706 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature