APP-CD74 axis mediates endothelial cell-macrophage communication to promote kidney injury and fibrosis.

ABSTRACT:

Background

Kidney injuries often carry a grim prognosis, marked by fibrosis development, renal function loss, and macrophage involvement. Despite extensive research on macrophage polarization and its effects on other cells, like fibroblasts, limited attention has been paid to the influence of non-immune cells on macrophages. This study aims to address this gap by shedding light on the intricate dynamics and diversity of macrophages during renal injury and repair.

Methods

During the initial research phase, the complexity of intercellular communication in the context of kidney injury was revealed using a publicly available single-cell RNA sequencing library of the unilateral ureteral obstruction (UUO) model. Subsequently, we confirmed our findings using an independent dataset

SUBMITTER: Liu B 

PROVIDER: S-EPMC11439715 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature