Gut microbiota and autoimmune thyroid disease: a bidirectional Mendelian randomization study and mediation analysis.

ABSTRACT:

Background

The gut microbiota (GM) plays a pivotal role in influencing various health outcomes, including immune-mediated conditions, but its potential association with autoimmune thyroid disease (AITD) remains underexplored. We aimed to investigate the potentially pathogenic or protective causal impacts of specific GM on two types of AITD, namely Graves' disease and Hashimoto's thyroiditis, and analyzed the mediating effect of 731 immune cell phenotypes.

Methods

Leveraging pooled genome-wide association study (GWAS) data of 211 gut microbiota traits, 731 immune cell phenotypes, and two types of AITD (Hashimoto's thyroiditis and Graves' disease), we performed bidirectional Mendelian randomization (MR) analyses to explore the causal relationships between the GM and AITD. Subs

SUBMITTER: Fang Y 

PROVIDER: S-EPMC11439789 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature