Correspondence between white matter hyperintensities and regional grey matter volumes in Alzheimer's disease.

ABSTRACT:

Objective

White matter hyperintensities (WMH) are the most common neuroimaging manifestation of cerebral small vessel disease, and is frequently observed in Alzheimer's disease (AD). This study aimed to investigate the relationship between WMH and cognition and to verify the mediation of grey matter atrophy in this relationship.

Methods

The diffusion tensor imaging (DTI) technique analyses white matter fiber tract to assess white matter integrity. Voxel-based morphometry was applied to measure the grey matter volume (GMV). A linear regression model was applied to examine the associations between WMH and GMV, and mediation analyses was performed to determine the mediating role of regional GMV in the effect of WMH on cognitive function.

Results

Compared to the HC group,

SUBMITTER: Yi F 

PROVIDER: S-EPMC11439820 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature