Restriction of salt, alcohol and coffee intake and Meniere's disease: insight from Mendelian randomization study.

ABSTRACT:

Background

Restricting salt, caffeine, and alcohol intake is commonly recommended as a first-line treatment for patients with Ménière's disease (MD). However, it remains unclear whether these interventions effectively improve symptoms of MD. Therefore, we conducted a bidirectional two-sample Mendelian randomization (MR) analysis to evaluate the relationship between these dietary modifications and MD.

Methods

Summary statistics for salt added to food, alcohol consumption, coffee consumption, and MD were sourced from the United Kingdom Biobank, GSCAN, and the FinnGen study, involving up to 941,280 participants. The main analyses were performed using the random-effects inverse-variance weighted (IVW) approach and were complemented by four additional methods. Multiple sensitivit

SUBMITTER: Gao W 

PROVIDER: S-EPMC11439828 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature