Volumetric modulated arc therapy total body irradiation improves toxicity outcomes compared to 2D total body irradiation.

ABSTRACT:

Introduction

Volumetric modulated arc therapy (VMAT) total body irradiation (TBI) allows for greater organ sparing with improved target coverage compared to 2D-TBI. However, there is limited evidence of whether improved organ sparing translates to decreases in toxicities and how its toxicities compare to those of the 2D technique. We aimed to compare differences in toxicities among patients treated with TBI utilizing VMAT and 2D techniques.

Methods/materials

A matched-pair single-institution retrospective analysis of 200 patients treated with TBI from 2014 to 2023 was performed. Overall survival (OS) and progression-free survival (PFS) were analyzed using the Kaplan-Meier method and compared using log-rank tests. Differences in characteristics and toxicities between the VMAT

SUBMITTER: Hui C 

PROVIDER: S-EPMC11439880 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature