Sucrose binge-eating and increased anxiety-like behavior in Sprague-Dawley rats exposed to repeated LPS administration followed by chronic mild unpredictable stress.

ABSTRACT: Exposure to persistent mild stress is a frequently encountered chronic challenge in a rapidly evolving society. Depending on various factors including sex, the response to stressors varies and is closely linked to the phenomenon of resilience. Depression and anxiety can be considered maladaptive responses to such stress. In this rat study, we investigated the sex-dependent effects of low-grade systemic inflammation during 1 week in combination with chronic unpredictable mild stress during the following 4 weeks on anxiety-like behavior and episodic feeding behavior. Increased anxiety-like behavior and increased sucrose intake were identified in stressed compared to control animals regardless of sex. Interestingly, two nearly equally distributed subpopulations were found in the stressed grou

SUBMITTER: Aranđelovic J 

PROVIDER: S-EPMC11439944 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature