A layered microcircuit model of somatosensory cortex with three interneuron types and cell-type-specific short-term plasticity.

ABSTRACT: Three major types of GABAergic interneurons, parvalbumin-, somatostatin-, and vasoactive intestinal peptide-expressing (PV, SOM, VIP) cells, play critical but distinct roles in the cortical microcircuitry. Their specific electrophysiology and connectivity shape their inhibitory functions. To study the network dynamics and signal processing specific to these cell types in the cerebral cortex, we developed a multi-layer model incorporating biologically realistic interneuron parameters from rodent somatosensory cortex. The model is fitted to in vivo data on cell-type-specific population firing rates. With a protocol of cell-type-specific stimulation, network responses when activating different neuron types are examined. The model reproduces the experimentally observed inhibitory effects of PV

SUBMITTER: Jiang HJ 

PROVIDER: S-EPMC11439972 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature