Neuroticism and posttraumatic stress disorder: A Mendelian randomization analysis.

ABSTRACT:

Objective

Epidemiological studies revealed an unestablished association between neuroticism and posttraumatic stress disorder (PTSD) and we conducted mendelian randomization (MR) analyses to examine whether neuroticism clusters of worry, depressed affect, and sensitivity to environmental stress and adversity (SESA) were involved in the development of PTSD.

Method

We obtained data on three neuroticism clusters, PTSD, and nine other psychiatric disorders from genome-wide association studies summary statistics and employed univariable, multivariable, and mediation MR analyses to explore causal associations among them.

Results

Neuroticism clusters were linked with PTSD (depressed affect (odds ratio [OR]: 2.94 [95% confidence interval: 2.21-3.92]); SESA (2.69 [1.95-3.71];

SUBMITTER: You Z 

PROVIDER: S-EPMC11440025 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature