Apathy and Impulsivity Co-Occur in Huntington's Disease.

ABSTRACT:

Background

Apathy is a debilitating behavioral change in Huntington's disease (HD), but impulsivity in HD has not been well documented, and the co-occurrence of these behaviors in HD has not been investigated.

Objective

Our objective was to determine whether apathy and impulsivity co-occur in people with HD and their associations with quality of life.

Methods

Carriers of Huntington's gene expansion (premanifest to mild motor manifest disease; n = 42) along with healthy controls (n = 20) completed measures of apathy (Apathy Evaluation Scale and Apathy Motivation Index) and impulsivity (Barratt Impulsiveness Scale-11 and UPPS-P impulsivity scale), along with mood, cognition, clinical, and quality of life measures. Apathy and impulsivity measures were each reduced to a s

SUBMITTER: Morris LA 

PROVIDER: S-EPMC11440026 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature