Serum CXCL13 as a Novel Biomarker in Oral Squamous Cell Carcinoma.

ABSTRACT:

Background

Despite its low sensitivity (approximately 30%), squamous cell carcinoma (SCC) antigen is commonly utilized as a serum tumor marker for oral SCC (OSCC) in clinical settings. The objective of this research was to identify novel biomarkers for OSCC.

Methods

Initially, we performed microarray analysis to evaluate the gene expression signatures of primary OSCC and normal oral mucosal tissues. Our findings showed the C-X-C motif chemokine ligand 13 (CXCL13) to be a promising novel biomarker as it was consistently overexpressed in primary OSCC tissues, a conclusion corroborated by polymerase chain reaction results. Subsequently, we measured serum CXCL13 levels in 125 patients with OSCC using a sandwich enzyme-linked immunosorbent assay and compared the results with thos

SUBMITTER: Tojo S 

PROVIDER: S-EPMC11440027 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature