Targeting NETosis in Acute Brain Injury: A Systematic Review of Preclinical and Clinical Evidence.

ABSTRACT: Acute brain injury (ABI) remains one of the leading causes of death and disability world-wide. Its treatment is challenging due to the heterogeneity of the mechanisms involved and the variability among individuals. This systematic review aims at evaluating the impact of anti-histone treatments on outcomes in ABI patients and experimental animals and defining the trend of nucleosome levels in biological samples post injury. We performed a search in Pubmed/Medline and Embase databases for randomized controlled trials and cohort studies involving humans or experimental settings with various causes of ABI. We formulated the search using the PICO method, considering ABI patients or animal models as population (P), comparing pharmacological and non-pharmacological therapy targeting the nucleosom

SUBMITTER: Savi M 

PROVIDER: S-EPMC11440106 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature