Oleuropein enhances proteasomal activity and reduces mutant huntingtin-induced cytotoxicity.

ABSTRACT:

Introduction

Huntington's disease (HD) is a hereditary neurodegenerative disorder that primarily affects the striatum, a brain region responsible for movement control. The disease is characterized by the mutant huntingtin (mHtt) proteins with an extended polyQ stretch, which are prone to aggregation. These mHtt aggregates accumulate in neurons and are the primary cause of the neuropathology associated with HD. To date, no effective cure for HD has been developed.

Methods

The immortalized STHdh ^Q111/Q111 striatal cell line, the mHtt-transfected wild-type STHdh ^Q7/Q7 striatal cell line, and N2a cells were used as Huntington's disease cell models. Flow cytometry was used to assess cellular reactive oxygen species and transfectio

SUBMITTER: Huang ZN 

PROVIDER: S-EPMC11440197 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature