Maternal Exposure to Tap Water Disinfection By-Products and Risk of Selected Congenital Heart Defects.

ABSTRACT:

Background

The use of chlorine to treat drinking water produces disinfection by-products (DBPs), which have been associated with congenital heart defects (CHDs) in some studies.

Methods

Using National Birth Defects Prevention Study data, we linked geocoded residential addresses to public water supply measurement data for DBPs. Self-reported water consumption and filtration methods were used to estimate maternal ingestion of DBPs. We estimated adjusted odds ratios and 95% confidence intervals using logistic regression controlling for maternal age, education, body mass index (BMI), race/ethnicity, and study site to examine associations between CHDs and both household DBP level and estimated ingestion of DBPs.

Results

Household DBP exposure was assessed for 2717 particip

SUBMITTER: Michalski AM 

PROVIDER: S-EPMC11440226 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature