Translocation in bone and soft tissue sarcomas: a comprehensive epidemiological investigation.

ABSTRACT:

Background

Limited epidemiological research has focused on translocations in soft tissue sarcomas, with no studies on bone sarcomas. This study aimed to clarify the epidemiology, prognosis, and genetic information of translocation-related sarcoma (TRS) and non-TRS patients.

Materials and methods

This retrospective cohort study used data from the Bone and Soft Tissue Tumor Registry in Japan (BSTTRJ) (2001-2019), the Kyushu University Hospital (KUH) repository (2001-2021), and a publicly available online dataset (MSK). The patients were categorized into TRS and non-TRS groups, and epidemiological, prognostic, and mutational diversity were compared.

Results

This study included 25 383 participants, of whom 4864 (19.2%) were TRS and 20 519 (80.8%) were non-TRS patients. TR

SUBMITTER: Kawaguchi K 

PROVIDER: S-EPMC11440303 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature