Longitudinal dynamics of the gut microbiome and metabolome in peanut allergy development.

ABSTRACT:

Background

Rising rates of peanut allergy (PA) motivate investigations of its development to inform prevention and therapy. Microbiota and the metabolites they produce shape food allergy risk.

Objective

We sought to gain insight into gut microbiome and metabolome dynamics in the development of PA.

Methods

We performed a longitudinal, integrative study of the gut microbiome and metabolome of infants with allergy risk factors but no PA from a multicenter cohort followed through mid-childhood. We performed 16S rRNA sequencing, short chain fatty acid measurements, and global metabolome profiling of fecal samples at infancy and at mid-childhood.

Results

In this longitudinal, multicenter sample (n = 122), 28.7% of infants developed PA by mid-childhood (mean age 9 yea

SUBMITTER: Chun Y 

PROVIDER: S-EPMC11440358 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature