Selective inhibition of cancer cell migration using a pH-responsive nucleobase-modified DNA aptamer.

ABSTRACT: Because of the extracellular acidic microenvironment of cancer cells, many pH-responsive molecules have become indispensable materials for bioanalysis and targeted therapy development. pH-Responsive DNA aptamers, which selectively bind to target proteins in cancer cells, have become a key research target in the therapeutic field. However, conventional pH-responsive aptamers have fatal drawbacks, such as complex structures, sequence limitation, and difficulties in mass production, as they require special nucleic acid structures, including the i-motif and DNA triplex. To address these issues, we utilized An^C, which is an unnatural nucleobase with a pK _aH of 5.9, to construct a simple pH-responsive DNA aptamer (CSL1-II) for selective binding to the c-Me

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11440363 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature