The Association between Leucocyte Telomere Length and Survival Outcomes in Patients with Cardiovascular Disease.

ABSTRACT:

Background

We explore the association between leucocyte telomere length (LTL) and all-cause and cardiovascular disease (CVD)-specific death in CVD patients.

Methods

We acquired 1599 CVD patients from a nationally representative US population survey for this study. We applied Kaplan-Meier curves, adjusted weighted Cox regression models, and restricted cubic spline to investigate the association between LTL and all-cause death. Additionally, we employed competing risk regression to assess the impact of LTL on cardiovascular-specific death, setting non-cardiovascular death as a competing event.

Results

The overall mortality rate was 31.0% after a median follow-up of 13.9 years. Patients with shorter LTL exhibited a higher risk of all-cause death, with an adjusted hazard

SUBMITTER: Sun JY 

PROVIDER: S-EPMC11440408 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature