Muscle fibre satellite cells are located at a greater distance from capillaries in patients with COPD compared with healthy controls.

ABSTRACT:

Background

COPD is a disease characterised by skeletal muscle dysfunction. A spatial relationship exists between satellite cells and muscle fibre capillaries, which has been suggested to be of major importance for satellite cell function. In the present study we compared the spatial relationship between satellite cells and capillaries in patients with COPD and age-matched healthy older adults.

Methods

Muscle biopsies were obtained from the vastus lateralis of n=18 patients with COPD (8 female, 10 male; age 66±5 years, mild-to-severe airflow obstruction) and n=18 age-, sex- and body mass index-matched healthy control adults (8 female, 10 male; age 68±5 years). Immunohistochemistry was used to assess type I/II muscle fibre size, distribution, myonuclear content, satelli

SUBMITTER: Betz MW 

PROVIDER: S-EPMC11440426 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature