Acylhydrazone-based reversibly photoswitchable ion pair transporter with OFF-ON cotransport activity.

ABSTRACT: The cellular membrane transport of physiologically important cations and anions is omnipresent and regulates different physiological functions. Whereas a notable number of cation-anion transporters are being developed to transport salts across the membrane, developing an artificial cation-anion symporter with stimulus-responsive activities is an immense obstacle. Herein, for the first time, we report reversibly photoswitchable acylhydrazone-based transporter 2 that has distinctive OFF-ON cation-anion co-transport abilities. The substituent was modified in 1a-1c and 2, to change the to-and-fro movement of the transporter to enhance the ion transport efficiency. Ion transport experiments across the lipid bilayer membrane demonstrate that 1a has the highest transport activity among the series

SUBMITTER: Chattopadhayay S 

PROVIDER: S-EPMC11440441 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature