High NTRK2 protein expression levels may be associated with poorer prognosis of breast cancer patients.

ABSTRACT:

Objective

Previous research has shown that the role of neurotrophic receptor tyrosine kinase 2 (NTRK2) in breast cancer (BRCA) remains ambiguous. To help elucidate this, we conducted a retrospective study to investigate the relationship between NTRK2 protein expression and BRCA.

Methods

The prognostic significance of NTRK2 protein expression patterns was assessed by performing immunohistochemistry assays on 131 BRCA tissues and 56 adjacent normal tissues in a retrospective study. Furthermore, the sensitivity to chemotherapeutic drugs was quantified by "pRRophetic" and the sensitivity to immunotherapy was estimated using The Cancer Immunome Atlas website.

Results

NTRK2 protein was expressed at significantly higher levels in BRCA samples compared with normal tissues. Th

SUBMITTER: Zhang R 

PROVIDER: S-EPMC11440626 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature