Streptokinase reduces Streptococcus dysgalactiae subsp. equisimilis biofilm formation.

ABSTRACT:

Background

Streptococcus dysgalactiae subspecies equisimilis (SDSE) is increasingly recognized as an emerging cause of invasive diseases including necrotizing soft tissue infections (NSTIs). In contrast to the closely related Streptococcus pyogenes, SDSE infections mainly affect older and comorbid patients. Biofilm formation has been demonstrated in soft tissue biopsies of S. pyogenes NSTI cases.

Results

Here, we show that bacterial aggregations indicative of biofilms are also present in SDSE NSTI. Although streptokinase (Ska) activity and biofilm formation did not correlate in a diverse set of clinical SDSE isolates, addition of exogenous Ska at an early time point prevented biofilm formation for selected strains. Deletion of ska in SDSE S118 strain resulted in increased bi

SUBMITTER: Tolken LA 

PROVIDER: S-EPMC11440690 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature