Effects of dynamic [¹⁸F]NaF PET scan duration on kinetic uptake parameters in the knee.

ABSTRACT:

Introduction

Accurately estimating bone perfusion and metabolism using [¹⁸F]NaF kinetics from shorter scan times could help address concerns related to patient comfort, motion, and throughput for PET scans. We examined the impact of changing the PET scan duration on the accuracy of [¹⁸F]NaF kinetic parameters in the knee.

Methods

Both knees of twenty participants with and without osteoarthritis were scanned using a hybrid PET-MRI system (53 ± 13 years, BMI 25.9 ± 4.2 kg/m², 13 female). Seventeen participants were scanned for 54 ± 2 min, and an additional three participants were scanned for 75 min. Patlak K _i and Hawkins kinetic parameters (K _i, K ₁, extraction fraction) were assessed using

SUBMITTER: Watkins LE 

PROVIDER: S-EPMC11440834 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature