A systematic evaluation of five different image-derived input functions for the clinical implementation of ¹⁸F-NaF bone PET/CT in patients with chronic kidney disease-mineral and bone disorder.

ABSTRACT:

Introduction

The aim of this study was to investigate the impact of the use of varying input parameters on resulting bone plasma clearance (K_i ) and other kinetic modelling parameters in a group of patients with chronic kidney disease-mineral and bone disorder (CKD-MBD).

Methods

Raw PET/CT data and blood data were systematically analyzed using five different VOIs for the input functions in the left ventricle and in the thoracic aorta. Standardized VOIs were placed in four thoracic vertebrae and the results pooled and averaged. The basic image-derived input functions (IDIFs) were corrected for partial volume effect and spill-over and modified by substitution of the terminal image exponential with the corresponding plasma-exponentials derived from blood sampl

SUBMITTER: Theil J 

PROVIDER: S-EPMC11440843 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature