Single-voxel delay map from long-axial field-of-view PET scans.

ABSTRACT:

Objective

We present an algorithm to estimate the delay between a tissue time-activity curve and a blood input curve at a single-voxel level tested on whole-body data from a long-axial field-of-view scanner with tracers of different noise characteristics.

Methods

Whole-body scans of 15 patients divided equally among three tracers, namely [¹⁵O]H₂O, [¹⁸F]FDG and [⁶⁴Cu]Cu-DOTATATE, which were used in development and testing of the algorithm. Delay times were estimated by fitting the cumulatively summed input function and tissue time-activity curve with special considerations for noise. To evaluate the performance of the algorithm, it was compared against two other algorithms also commonly applied in delay estimation: name cross-correl

SUBMITTER: Nielsen FB 

PROVIDER: S-EPMC11440851 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature