Fully Automated ⁶⁸Ga-Labeling and Purification of Macroaggregated Albumin Particles for Lung Perfusion PET Imaging.

ABSTRACT: Lung PET/CT is a promising imaging modality for regional lung function assessment. Our aim was to develop and validate a fast, simple, and fully automated GMP compliant [⁶⁸Ga]Ga-MAA labeling procedure, using a commercially available [^99mTc]Tc-MAA kit, a direct gallium-68 eluate and including a purification of the [⁶⁸Ga]Ga-MAA. Method: The synthesis parameters (pH, heating temperature) were manually determined. Automated ⁶⁸Ga-labeling of MAA was then developed on a miniAIO (Trasis®, Ans, Belgium) module. An innovative automated process was developed for the purification. The process was then optimized and adapted to automate both the [⁶⁸Ga]Ga-MAA synthesis and the isolation of gallium-68 eluate required for the pulmonary ventilat

SUBMITTER: Blanc-Beguin F 

PROVIDER: S-EPMC11440869 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature