Mutational signatures in 175 Chinese gastric cancer patients.

ABSTRACT:

Background

Gastric cancer (GC), a molecularly heterogeneous disease, is the third leading cause of cancer death worldwide. The majority of GC cases worldwide occur in East Asia, predominantly China. Mutational Signature Framework offers an elegant approach to identify mutational processes present in tumors.

Methods

To identify mutational signature patterns, we conducted whole exome sequencing (WES) analysis in Chinese patients with GC. Mutect2 and MutsigCV were used to identify significantly mutated genes in 175 Chinese GC cases using paired tumor-normal tissues. We investigated mutational signatures using Catalogue of Somatic Mutations in Cancer (COSMIC) Version 2 (V2) and Version 3 (V3).

Results

We identified 104 mutated genes with P < 0.01. Seven genes (OR6B1, B2M,

SUBMITTER: Liu F 

PROVIDER: S-EPMC11440915 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature